Aims
To assess the relative toxicity of specific tricyclic antidepressants (TCAs), a serotonin and noradrenaline reuptake inhibitor (SNRI), a noradrenergic and specific serotonergic antidepressant (NaSSA), and selective serotonin reuptake inhibitors (SSRIs).
Method
Observational study of prescriptions (UK), poisoning deaths involving single antidepressants receiving coroners’ verdicts of suicide or undetermined intent (England and Wales) and non-fatal self-poisoning episodes presenting to six general hospitals (in Oxford, Manchester and Derby) between 2000 and 2006. Calculation of fatal toxicity index based on ratio of rates of deaths to prescriptions, and case fatality based on ratio of rates of deaths to non-fatal self-poisonings.
source
Toxicity of antidepressants: rates of suicide relative to prescribing and non-fatal overdose
Keith Hawton, DSc, Helen Bergen, PhD and Sue Simkin, BA
Jayne Cooper, PhD
Keith Waters, RMN
David Gunnell, PhD
Navneet Kapur, MD
To assess the relative toxicity of specific tricyclic antidepressants (TCAs), a serotonin and noradrenaline reuptake inhibitor (SNRI), a noradrenergic and specific serotonergic antidepressant (NaSSA), and selective serotonin reuptake inhibitors (SSRIs).
Method
Observational study of prescriptions (UK), poisoning deaths involving single antidepressants receiving coroners’ verdicts of suicide or undetermined intent (England and Wales) and non-fatal self-poisoning episodes presenting to six general hospitals (in Oxford, Manchester and Derby) between 2000 and 2006. Calculation of fatal toxicity index based on ratio of rates of deaths to prescriptions, and case fatality based on ratio of rates of deaths to non-fatal self-poisonings.
source
Toxicity of antidepressants: rates of suicide relative to prescribing and non-fatal overdose
Keith Hawton, DSc, Helen Bergen, PhD and Sue Simkin, BA
Jayne Cooper, PhD
Keith Waters, RMN
David Gunnell, PhD
Navneet Kapur, MD
No comments:
Post a Comment
Note: only a member of this blog may post a comment.