blogs created to prevent or detect a crime http://www.opsi.gov.uk/acts/acts1997/ukpga_19970040_en_1

This blog is brougt to you consistent with subsection 3 of the Protection from Harassment Act - i.e. blogs created to prevent or detect a crime http://www.opsi.gov.uk/acts/acts1997/ukpga_19970040_en_1



Tuesday 31 August 2010

EUROPEAN MEDICINES AGENCY - Fiddaman on multiple serotonergic psychiatric drugs NOT just Seroxat

Name 195.144.18.254






IP Address 195.144.18.254

ISP EUROPEAN MEDICINES AGENCY

Domain -
City -
Region -
Country UNITED KINGDOM
Returning Visits 3



Date Time WebPage    



August 31, 2010 6:0:02 PM SEROXAT SUFFERERS - STAND UP AND BE COUNTED: Fiddaman on multiple serotonergic psychiatric drugs NOT just Seroxat - criticalpsychiatry
 
 
http://bobfiddaman.blogspot.com/2010/08/fiddaman-on-multiple-serotonergic.html

EUROPEAN MEDICINES AGENCY check out BBC Panorama Avandia scare stories

Name 195.144.18.254


IP Address 195.144.18.254

ISP EUROPEAN MEDICINES AGENCY

Domain -

City -

Region -

Country UNITED KINGDOM

Returning Visits 0

Date Time WebPage

August 31, 2010 5:03:32 PM SEROXAT SUFFERERS - STAND UP AND BE COUNTED: Avandia scare stories - Experts ease fears over Glaxo drug By Daily Mail Reporter

http://bobfiddaman.blogspot.com/2010/07/avandia-scare-stories-experts-ease.html

http://www.google.co.uk/search?sourceid=navclient&ie=UTF-8&rls=GGLG,GGLG:2010-10 ,GGLG:en&q=bbc panorama avandia

Fiddaman on multiple serotonergic psychiatric drugs NOT just Seroxat - criticalpsychiatry

Fiddaman said -

"I take 40mg of Paroxetine (Seroxat) per day for depression.50mg Tramadol per day for my arthritis.75mg Dothiepan just before bedtime (another anti depressant though my GPsays it should help me get a better sleep)15mg Zoton (Reflux Osophugus)"

source
http://groups.google.co.uk/group/uk.people.disability/browse_thread/thread/b0ba9fc3e9295d81?hl=en-GB&q=fiddaman+benefit
see also -
http://health.groups.yahoo.com/group/criticalpsychiatry/message/63577

early BBC video on SSRI's - with David Healy & comments on Prozac, Lustral & Seroxat

http://www.bbc.co.uk/wales/weekinweekout/media/mindgames.ram


to play above you will need "Real Player"


available here - http://uk.real.com/realplayer



Mind Games






An eminent psychiatrist from Wales has risked his reputation to take on major drug companies over his belief that a group of anti-depressants can provoke suicidal tendencies in a minority of patients.





Watch the full Week In Week Out programme

You'll need to install Real's free players to watch this clip. Get help on installing RealPlayer, and watching BBC clips online.



On their introduction, Selective Serotonin Re-Uptake Inhibitors, or SSRIs, were heralded as a so-called 'magic bullet' solution to depression. Prescriptions of SSRIs such as Prozac and Seroxat have increased considerably in the UK since the mid-1990s, to around 18,000 prescriptions last year.



BBC Wales' award-winning current affairs programme Week In Week Out highlights concern that, although these drugs have proved beneficial for many patients, a small sub-group of patients may be susceptible to severe withdrawal symptoms after they stop taking one type of drug, and intense agitation leading to suicidal ideation when taking others.



Pharmaceutical companies strenuously deny the claims and insist that the drugs are a safe, effective treatment.



However Doctor David Healy, of the University of Wales College of Medicine, claims his own clinical research into one of the SSRI group of drugs, Lustral - or Zoloft as it is known in the US - shows that it can cause suicidal thoughts in some patients.



Dr Healy, who is director of the North Wales department of psychological medicine at Bangor, was offered a top research job in the Canadian city of Toronto, which was withdrawn after he delivered a lecture in which he claimed that SSRIs could cause a minority of patients to feel suicidal. After a lengthy dispute, he has now reached an out-of-court settlement with his prospective Canadian employers.



Dr Healy conducted his own clinical research study on Lustral two years ago, using a group of colleagues who were not suffering depression. Two of the volunteers became severely agitated and disturbed, and one even developed suicidal thoughts.



This volunteer, Isobel Logan, tells the programme, "I really thought, 'I just want to hang myself.' I felt so low, so depressed."



Dr Healy, who has given expert testimony in a number of high-profile medical negligence cases associated with SSRIs in the US, says, "The extraordinary finding was that when you give these drugs to people who aren't suited to them, you can make healthy volunteers agitated and suicidal on these drugs, within a week or two of them being on the drug."



However, Dr Healys research has been criticised in some quarters.



Meanwhile, a Cardiff firm of solicitors is considering launching a possible class action against the makers of Seroxat, GlaxoSmithKline. Medical negligence lawyer Mark Harvey, of Hugh James Solicitors, has been contacted by around 150 people from across the UK who claim to have experienced problems with Seroxat, including severe withdrawal symptoms when they tried to stop taking the drug.



Mother-of-two Paula Boddington tells the programme that she suffered electric-shock type sensations in her head and an irrational compulsion to harm herself when she tried to come off the drug.



Mark Harvey tells the programme, "People have often gone into their doctors, either feeling stressed or having mild panic attacks, and the doctor says, this tablet will give you a nice pick-you-up, and they feel good ... then they find that, when they go to come off the drug, the doctor understandably thinks that (the withdrawal symptoms) are the original condition, so they re-prescribe, and then they get into this vicious circle where they are taking the tablets more and more, feeling worse and worse."



But GlaxoSmithKline, manufacturers of Seroxat, deny that the drug is addictive.

Scientology's Andy Vickery admits targeting GSK's Seroxat / Paxil

Andy Vickery


Trial Lawyer



http://www.justiceseekers.com/default.aspx?menuitemid=158

Although I have neither sought nor obtained a specialty designation or "board certification" from the Texas Bar, at the present time my practice is focused almost exclusively on cases involving pernicious side effects of antidepressant medications, mainly Paxil.

Monday 30 August 2010

SEROXAT IN THE MEDIA - Panorama stage managed like a Philip Marlowe thriller

BMJ. 2002 October 19; 325(7369): 910. PMCID: PMC1124413



http://health.groups.yahoo.com/group/criticalpsychiatry/message/63562


Copyright © 2002, BMJ

TV

Panorama: "The Secrets of Seroxat"

P J Cowen, professor of psychopharmacology

University of Oxford ; Email: phil.cowen@...

• Other Sectionsâ–¼



BBC 1, 13 October at 10 15 pm. Rating:

The postmodern media critic Jean Baudrillard once asserted that the Gulf war did not happen, and was only a televised simulation of a war. By the end of Panorama's "The Secrets of Seroxat" my own grip on reality, never particularly strong, was faltering. This mental fragility disappointed me because I know quite a lot about selective serotonin reuptake inhibitors (SSRIs), having prescribed them, done research on them, and taken them. It may have been the nature of Panorama's "secrets" that undermined me. For example, the Shorter Oxford Textbook of Psychiatry notes both the key issues raised in the programme, namely that SSRIs, particularly paroxetine (Seroxat), can cause unpleasant withdrawal symptoms and that early in SSRI treatment restlessness and agitation might increase the risk of suicidal behaviour.

Despite this it seems likely that clinicians and patients aren't sufficiently aware of these problems. Panorama featured the video diary of Helen Kelsall, which gave a superb account of how hard it can be for some people to stop SSRI treatment. However, far darker things were in store and at the centre of the programme was the kind of horrifying tragedy that depression can visit on its victims and their families. After being on paroxetine for two days retired American oilman Donald Shell shot and killed three members of his family (including his 9 month old granddaughter) before taking his own life. Such disasters have happened before SSRI treatment and will occur after SSRIs have left the scene. However, the family blamed the paroxetine and sued.

Tragedies like this have multiple causes and it is impossible to know for sure to what extent paroxetine might have played a role. However, Panorama staged its documentary as a thriller with David Healy as hero, a kind of psychiatric Philip Marlowe, walking the mean streets down which a man must go. Healy, reader in psychological medicine at the University of Wales College of Medicine, was interviewed under true film noir conditions; half his face was in darkness while the rest was lit like a Rembrandt. Later we saw him driving alone, grim jawed and dauntless, through a dark winding tunnel to the Harlow headquarters of GlaxoSmithKline, a soulless Lubyanka overhung with swirling banks of cloud. Healy's quest "bordering on the impossible" was to identify crucial documents in a sealed warehouse packed with a quarter of a million pieces of paper. These documents, which held the closely guarded secret that SSRIs can cause adverse effects in healthy volunteers, could win the case for the Shell family. Healy eventually arrived in a dark cavern, lined with boxes. Suddenly, there was light. The rest was history and six million dollars to the plaintiff.

Of course, if there are heroes there must be villains and drug companies rival clearing banks and Saddam Hussein in public affection. Unfortunately for the company spokesmen, in the hyper-reality of television, choreographed anecdote will beat evidence based medicine every time. In the face of human misery and disaster, attempts to put depression, its treatment, and the risk of suicide in a statistical context only make you appear heartless and evasive.

Why are we sometimes slow to recognise drug problems and share our knowledge with colleagues and patients? Better information systems and the internet will help, but drug companies have two difficult missions: they must discover new, safe medical treatments and at the same time maximise profits for shareholders. These goals don't have to be incompatible because knowing about the possible problems of medications increases the likelihood that we will use them safely and well. However, company representatives can find it difficult to acknowledge weaknesses in their products. Perhaps the industry needs a new kind of marketing culture for a more informed and sceptical public.

Another factor peculiarly relevant to psychiatry is the stigma and misunderstanding that surround the illnesses and their treatment. For example, the narrator in the Panorama programme repeatedly referred to SSRIs as "happy pills," a term which trivialises depression and insults people taking medication. Now, who were the good guys again?

Scientology Birmingham Ideal Org Land Deal(s) - video




http://www.youtube.com/watch?v=Pr4qL9QD2ns

Sunday 29 August 2010

Secrets of Seroxat - BBC Panorama criticised by Duncan Double

The facts of antidepressant discontinuation reactions

http://www.bmj.com/content/325/7369/910.1.extract/reply#bmj_el_26377


D B Double, Consultant Psychiatrist and Honorary Senior Lecturer

Norfolk Mental Health Care NHS Trust and University of East Anglia

I agree with Phil Cowen about the poor quality of the Panorama programme on the "Secrets of Seroxat".1 It is unfortunate that the issue of antidepressant discontinuation reactions has been monopolised by experts like David Healy, who tend to adopt a maverick position in psychiatry.2 The public is being presented with too many "facts" which may not be true.3




Nonetheless the medical profession was slow to acknowledge the significance of antidepressant discontinuation reactions. It is not so long ago that the Defeat Depression campaign of the Royal Colleges of Psychiatrists and General Practitioners advocated educatingpatients that discontinuing antidepressant treatment will notbe a problem.4 Even when the issue was recognised in an editorial in the BMJ the problems were minimised.5 A few years later the authors of the editorial had to update their views to admit that such reactions are common.6 There is at least ambiguity about the authority of the statement that antidepressants are not addictive.7



Some of the pharmaceutical companies may not have helped scientific debate because of misleading promotion of their products. Placebo responses to antidepressants are common, so withdrawing such medication may be expected to cause discontinuation problems as a nocebo effect. The difficulty is to establish how much neuroadaptation plays a role. The evidence may not be strong for physical dependence, but the importance of psychological dependence on antidepressants and other medication should not be disregarded by doctors. There is concern about this issue as witnessed by public interest in The Antidepressant Discontinuation Reactions website (http://www.uea.ac.uk/~wp276/antidepressant.htm).







1. Cowen PJ. Review of Panorama: "The Secrets of Seroxat".BMJ 2002; 325: 910 ( 19 October ) [Full text]



2. Double DB. Maverick medicine: Book review of The Creation of Psychopharmacology (2002) by David Healy. Health Service Journal 2002; 112 (5809): 42-43



3. Double DB. Book review of The anti-depressant fact book (2001) by PR Breggin. Metapsychology Online Review:8 December 2001 [Full text]



4. Double DB. Prescribing antidepressants in general practice. People may become psychologically dependent on antidepressants. (letter) BMJ 1997; 314: 826. [Full text]



5. Double DB. Antidepressant discontinuation reactions - dependence on antidepressants is significant. bmj.com/cgi/eletters/316/7138/1105#16, 1 May 1998 [Full text]



6. Double DB. Antidepressant discontinuation reactions - Haddad et al have updated their views. bmj.com/cgi/eletters/316/7138/1105#7244, 1 Apr 2000 [Full text]



7. Double DB. What does it mean to say that antidepressants are not addictive? bmj.com/cgi/eletters/318/7192/1188#3012, 30 Apr 1999 [Full text]

Dr David Healy says: ''I certainly wouldn't ban Seroxat. I still prescribe it.

quotes-


Dr David Healy, director of the University of North Wales department of psychological medicine and a world authority on Seroxat, says: ''I'm not in favour of withdrawing Seroxat because some of the people I treat are so disabled by their condition that they consider it worth the risks. My concern is that some people who have had no previous hostile thoughts get those thoughts after going on to the drug. Also some people have committed suicide after going on to Seroxat. Patients need to be told about these risks.'' The patient information leaflet does not mention them


source -

http://www.heraldscotland.com/sport/spl/aberdeen/the-jekyll-and-hyde-effect-a-woman-walked-free-from-court-earlier-this-year-after-attacking-another-woman-and-blaming-it-on-the-side-effects-of-the-anti-depressant-drug-seroxat-anne-johnstone-investigates-1.101064


quotes


Dr David Healy says: ''I certainly wouldn't ban Seroxat. I still prescribe it. The problem is that people with mild depression are being given the idea that these things are harmless. If they knew the facts, I think many would opt for self-help instead.''

Saturday 28 August 2010

Scientology TentacleWiki -Tracking Scientology on the net

http://home.primus.ca/~ronsharp/tentacle.zip

source  

message board is for ex Scientologists to freely discuss mutual experiences in Scientology. It covers such topics as L. Ron Hubbard, David Miscavige and current management, auditing and training, Ethics tech and its application, OSA, fair game, Clear & OT levels, Freewinds, and recovering from a cult experience.


http://www.forum.exscn.net/showthread.php?p=365843

193.35.158.39 - Whois Information = Cornwall County Council

193.35.158.39 - Whois Information

% Information related to '193.35.158.0 - 193.35.161.255'
inetnum: 193.35.158.0 - 193.35.161.255
netname: CORNWALL-CC
descr: Cornwall County Council
descr: Local Government Network
descr: Truro Cornwall
country: GB
admin-c: JOQ1-RIPE
tech-c: JOQ1-RIPE
mnt-by: RIPE-NCC-HM-PI-MNT
mnt-lower: RIPE-NCC-HM-PI-MNT
mnt-by: CORNWALLCC-MNT
mnt-routes: BTNET-MNT
mnt-domains: CORNWALLCC-MNT
mnt-domains: BTNET-MNT
status: ASSIGNED PI
source: RIPE # Filtered



person: John O Quick
address: Central Computer Services
address: Cornwall County Council
address: Old County Hall
address: Truro
address: Cornwall TR1 3BD
address: United Kingdom
phone: +44 872 322000
fax-no: +44 872 323800
e-mail: jquick@cornwall.gov.uk
nic-hdl: JOQ1-RIPE
source: RIPE # Filtered
% Information related to '193.35.158.0/23AS2856'

Friday 27 August 2010

CORNWALL COUNTY COUNCIL checking out Bob Fiddaman blogspot

Visitor Information: 193.35.158.39 (CORNWALL COUNTY COUNCIL) [Label Visitor]


Location: -, -, UNITED KINGDOM (CORNWALL.GOV.UK)

Last Visit Time: August 26, 2010 1:51:04 AM Length of this Visit: 0 hours and 4 minutes

Page Viewed This Visit: 1 Returning Visits: 

Entry Page: http://bobfiddaman.blogspot.com/2009/08/christopher-pittman-new-trial-hearing.html

Exit Page: http://bobfiddaman.blogspot.com/2009/08/christopher-pittman-new-trial-hearing.html

Referrer: http://www.google.co.uk/imgres?imgurl=http://2.bp.blogspot.com/_f_SNmaIfrzM/ShJq2Lv JnzI/AAAAAAAAASE/0mZf3uMNSqY/S227/simon%2Bgregor.jpg&imgrefurl=http://bobfiddaman.blogspot.com/2009/ 08/christopher-pittman-new-trial-hearing.html&usg=__12d5kPGVjSU1iRN9Q32Z

BBC taking a keen interest in Bob Fiddaman blogspot !

Host Name webgw4.thls.bbc.co.uk


IP Address 132.185.240.124

ISP BRITISH BROADCASTING CORPORATION

Domain BBC.CO.UK

City LONDON

Region ENGLAND

Country UNITED KINGDOM

Returning Visits 6

Date Time WebPage

August 27, 2010 12:29:26 PM SEROXAT SUFFERERS - STAND UP AND BE COUNTED: Seroxat blog ratings rigged by Toronto reader - the evidence is clear !

http://bobfiddaman.blogspot.com/2010/08/seroxat-blog-ratings-rigged-by-toronto.html

http://www.google.co.uk/search?hl=en&q=SHELLEY JOFRE seroxat&aq=f&aqi=&aql=&oq=& gs_rfai=

August 27, 2010 12:23:48 PM SEROXAT SUFFERERS - STAND UP AND BE COUNTED: uksurvivors : Message: Shelley Jofre Panorama programme removed after complaint

http://bobfiddaman.blogspot.com/2010/02/uksurvivors-message-shelley-jofre.html

http://www.google.co.uk/search?hl=en&&sa=X&ei=9ZV3TLMCipCMB8iC4JYG&ved=0CCEQBSgA &q=SHELLEY JOFRE&spell=1

Austin CCHR checking out Rover's Fiddaman

Visitor Information: rrcs-71-42-141-39.sw.biz.rr.com (ROAD RUNNER HOLDCO LLC) [Label Visitor]


Location: AUSTIN, TEXAS, UNITED STATES (RR.COM)

Last Visit Time: August 26, 2010 6:17:35 PM Length of this Visit: 0 hours and 0 minutes

Page Viewed This Visit: 1 Returning Visits: 0

Entry Page: http://bobfiddaman.blogspot.com/2010/08/citizens-commission-on-human-rights.html

Exit Page: http://bobfiddaman.blogspot.com/2010/08/citizens-commission-on-human-rights.html

Referrer: No referrer

I can walk as good as the rest of 'em - but I can't work @ Land Rover !

You don't have to be confined to a wheelchair to be classed as disabled! I never knew such narrow - minded people still existed.

http://groups.google.co.uk/group/alt.rock-n-roll.acdc/browse_thread/thread/646bf3b0103facd3/92c0a6e2af8b2676?hl=en&ie=UTF-8&q=fiddaman

I have osteoarthritis of both hips - my employer, Land Rover, cannot/will
not find me alternative work nor make reasonable adjustments to the
workplace.

I can walk as good as the rest of 'em though it does cause discomfort.

Heatseeker, blind people are disabled - do you see what I'm getting at.

Seroxat's Fiddaman claimed £44,000 from luxury car maker LandRover - June 2001

http://www.teamluxury.com/cars/seroxats-fiddaman-claimed-%C2%A344000-from-luxury-car-maker-landrover-june-2001/

Seroxat's Fiddaman claimed £44,000 from luxury car maker LandRover - June 2001

June 2001 - Bob Fiddaman claimed £44,000 from LandRover







source - http://groups.google.com/group/alt.rock-n-roll.acdc/browse_thread/thread/54c1b222a78b9c44?hl=en&ie=UTF-8&oe=UTF-8&q=%27Fiddy+to+start+work+at+Rover%27


I have to show the tribunals that I am willing to do whatever it is they offer me with restrictions. This is NOT the end of the matter. We are now asking for compensation for the time that I have been off work - Total of £44,000 --
And Remember......
KEEP IT STIFF

SHELLEY JOFRE (BBC) blows Mark Harvey's Seroxat case to pieces



source - http://coventryuniversity.podbean.com/2007/11/01/one-woman-a-multinational-and-a-victory-shelley-jofre-panorama/

Jeremy Bryce said:



2.30 in Jofre says - ” read a little bit in news paper about patients complaints” year 2000 about ” Seroxat difficult to withdraw from” .. Jofre found it intriguing Jofre had only just started working on Panorama at that stage



3.30 in ” Jofre calls SSRI’s “SELECTIVE Serotonin Reuptake Inhibitors”



4.14 Jofre knew little of how the pharmcutical industry worked



4 .30 in Ed says - lets look at antidepressant story



4 45 Jofre says although problems with whole class of antidepressants we (bbc) decided to concentrate on Seroxat Why we narrowed down on Seroxat 1 because it was made by GSK 2 all the drugs in class cause suicidal thinking on dose change 3 Seroxat had a unique problem of withdrawal BECAUSE IT WAS LONGER ACTING … we decided to focus research into this drug



6.00 in - 40 min Panorama film took Shelley Jofre 8 months to make



6.10 in - It’s not something you do lightly WE WERE TAKING ON the worlds second largest drug company



7.30 We were talking to the lawyer the whole way through production



9.30 in - Jofre says “we took a punt” on Dr David Healy

Fiddaman may have been forgotten by Rover but not by his masters @ CCHR/Scientology

Visitor Information: 66.120.47.69 (CITIZENSCOMMHUNRGHTS) [Label Visitor]


Location: PLANO, TEXAS, UNITED STATES

Last Visit Time: August 26, 2010 5:22:04 PM Length of this Visit: 0 hours and 0 minutes

Page Viewed This Visit: 1 Returning Visits: 0

Entry Page: http://bobfiddaman.blogspot.com/2010/08/citizens-commission-on-human-rights.html

Exit Page: http://bobfiddaman.blogspot.com/2010/08/citizens-commission-on-human-rights.html

Referrer: No referrer

CCHR texas checking out Rovers forgotten man Bob Fiddaman

Visitor Information: 66.120.47.69 (CITIZENSCOMMHUNRGHTS) [Label Visitor]


Location: PLANO, TEXAS, UNITED STATES

Last Visit Time: August 26, 2010 6:13:16 PM Length of this Visit: 0 hours and 8 minutes

Page Viewed This Visit: 2 Returning Visits: 1

Entry Page: http://bobfiddaman.blogspot.com/2010/08/citizens-commission-on-human-rights.html

Exit Page: http://bobfiddaman.blogspot.com/2010/08/citizens-commission-on-human-rights.html

Referrer: No referrer

CCHR checking out their stooge Bob Fiddaman

Visitor Information: 66.120.47.69 (CITIZENSCOMMHUNRGHTS) [Label Visitor]


Location: PLANO, TEXAS, UNITED STATES

Last Visit Time: August 26, 2010 7:02:58 PM Length of this Visit: 0 hours and 0 minutes

Page Viewed This Visit: 1 Returning Visits: 0

Entry Page: http://bobfiddaman.blogspot.com/2010/08/citizens-commission-on-human-rights.html

Exit Page: http://bobfiddaman.blogspot.com/2010/08/citizens-commission-on-human-rights.html

Referrer: No referrer

CCHR Texas checking out their boy Bob Fiddaman - link from SSRIcrusaders

Visitor Information: 66.120.47.69 (CITIZENSCOMMHUNRGHTS) [Label Visitor]


Location: PLANO, TEXAS, UNITED STATES

Last Visit Time: August 26, 2010 10:09:44 PM Length of this Visit: 0 hours and 0 minutes

Page Viewed This Visit: 1 Returning Visits: 2

Entry Page: http://www.bobfiddaman.blogspot.com/

Exit Page: http://www.bobfiddaman.blogspot.com/

Referrer: http://health.groups.yahoo.com/group/SSRI-Crusaders/message/34722

CCHR texas checking out Bob Fiddaman - link from criticalpsychiatry

Visitor Information: 66.120.47.69 (CITIZENSCOMMHUNRGHTS) [Label Visitor]


Location: PLANO, TEXAS, UNITED STATES

Last Visit Time: August 27, 2010 1:11:36 AM Length of this Visit: 0 hours and 7 minutes

Page Viewed This Visit: 3 Returning Visits: 17

Entry Page: http://www.bobfiddaman.blogspot.com/

Exit Page: http://www.bobfiddaman.blogspot.com/

Referrer: http://health.groups.yahoo.com/group/criticalpsychiatry/message/58725

Thursday 26 August 2010

Scientology's LEAF Project - Letters To The Editor Attack Force - Exposed

Scientology's LEAF Project - Letters To The Editor Attack Force - Exposed


Every thing in Scientology is choreographed... a SHOW, an apparency,

designed to leave the uniformed public confused and to provide an
apparency of agreement that there is belief is a certain desired
fallacy that benefits the coffers of $cientology.



Teen Screen is legislation to interview school kids to prevent

SUICIDES...that is opoosed by the scam of scientology, because it is
based upon psychology and psychiatry...

I never had any doubt that all the letters to editors and the anti-
psych spam was coordinated, but you'll LOVE THIS:

"LEAF" = Letters to the Editor Attack Force

It was / is an actual group set up to do this...

Run by Doyle Mills, CW scientologist and OSA volunteer. He also works at Digital Light Wave

Note that in some of the letters he says: "report compliance by email"

So his "LEAF" operatives are commanded to report completion of
assignments back to him!

Scientology world headquarters located Clearwater Florida - known as Flag Land Base

Clearwater, Florida - Wikipedia, the free encyclopedia


The worldwide headquarters of the Church of Scientology are located in downtown Clearwater, Florida. Officially known in Scientology as Flag Land Base, ...


en.wikipedia.org/wiki/Clearwater,_Florida

Wednesday 25 August 2010

Citizens Commission on Human Rights a scientology front group - video



http://www.youtube.com/watch?v=7SAFFM1sFZA

Citizens Commission on Human Rights exposed as a Scientology front - wikileaks

Release date

http://sunshinepress.org/wiki/Citizens_Commission_on_Human_Rights_exposed_as_a_Scientology_front


March 7, 2008



Note



Wikileaks has made public the submission, since the material is no longer available at the link described earlier today.

Download

http://file.wikileaks.org/file/cchr-mails.zip

File
Torrent
Magnet

Further information



Context

United States

Non-governmental organization

Citizens Commission on Human Rights

Primary language



English

File size in bytes



282977

File type information



Zip archive data, at least v1.0 to extract

Cryptographic identity



SHA256 bcf6936c8d2d4865d1802b334934e4bb72db7b7b2d2a32b494d1a0d0c9473895

Description (as provided by our source)



1. Download link just released into the chat forums at: http://forums.enturbulation.org/viewtopic.php?f=12&t=6059



2. The file contains e-mails between members of CCHR (an anti-psychiatry front group of the Church of Scientology)



3. Likely audience: anyone seeking psychological care for themselves or a loved one.



4. Visit the forum via the link above to join in the discussion of these leaked e-mails, and view the original post by the individual who leaked them. You may private message the individual there.



5. It was leaked for a number of reasons:



- Scientology denies that it is behind CCHR (which is clearly contradicted by the references in the emails)



- It shows, clearly, how Scientologists and the CCHR are deliberately manipulating the media... using false accounts and sock puppetry to skew information.



- It shows just how Machiavellian and hypocritical the CCHR is in their planning and execution of attacks against peer-reviewed medical science.



6. Yes. The CCHR's campaign of misinformation is designed specifically to derail people seeking psychiatric help, and instead funnel them toward Scientology. This nonsense, and lack of peer-reviewed treatment CCHR recommends instead (vitamins, niacin, hot saunas) is likely to harm rather than hel

Tuesday 24 August 2010

Scientology cult Canada CCHR financing - wikileaks

Release date


August 10, 2008



Download

http://wikileaks.org/wiki/Scientology_cult_Canada_CCHR_financing

File
Torrent
Magnet

Further information



Context

Canada

Cults and religious organizations

Scientology

Primary language



English

File size in bytes



38088

File type information



Rich Text Format data, version 1,

Cryptographic identity



SHA256 19c0bcf8b647a35be98c4b8002b562df4a3e0cbc17d633149d886e68d9d02e2e

Description (as provided by our source)



1. Online on enturbulation.org, but not complete. This version has the headers.



2. Evidence that CoS runs the front group.



CCHR pres/director in Qu�bec, Denis Cot�, lied on the media about the fact that they were never financed by Scientology. We have him trying intentionally to stop a big Scientific facility from being built in Quebec City: Neurocite (and it involves a big scilon businessman).



3. Qu�bec and Canada media, activists, Anonymous.



4. Ex-Scientologists at forum.exscn.net, as well as www.exscientologykids.com can confirm veracity of the contents.



5. To inform the public that the cult is attempting to stop the construction of a research facility in Quebec and to provide evidences of the connection between Scientology and the CCDH (CCHR in English)

Sunday 22 August 2010

GSK & The forgotten children of Ireland's hidden vaccine scandal

http://www.independent.ie/national-news/the-forgotten-children-of-irelands-hidden-scandal-2305062.html

SUSPICIONS that vaccine trials had taken place on vulnerable Irish children -- many of whom were in state care -- first surfaced in the early 1990s.

As the current decade dawned, former residents of children's homes began to publicly raise concerns that they had been the subject of experimental trials.

However, it was not until 1997 that the State gave an assurance that it would formally inquire into the issue.

Brian Cowen, who was then Health Minister, directed the chief medical officer at the Department of Health, Dr James Kiely, to investigate the allegations.

In 2000, a report -- entitled the "Report On Three Clinical Trials Involving Babies And Children In Institutional Settings, 1960/61, 1970 and 1973" -- was finally drawn up.

The document found that 211 children had been administered vaccines during three separate vaccine trials conducted on behalf of a drugs company, The Wellcome Foundation.

More than 123 of these infants and toddlers were residents in children's homes in Dublin, Cork and the midlands when the trials took place in the 1960s and 1970s.

Trial one involved 58 children in five children's homes in Dublin, Cork, Westmeath and Meath. The trial investigated what would happen if four vaccines -- diphtheria, pertussis (also known as whooping cough), tetanus and polio -- were combined in one overall four-in-one shot.

The trial was published in the 'British Medical Journal' in 1962. The final paragraph of it read: "We are indebted to the medical officers in charge of the children's homes. . . for permission to carry out this investigation on infants under their care."

Trial two, which was conducted during the summer of 1970, saw 35 children administered with the intra-nasal rubella vaccine.

It involved children from St Anne's Industrial School in Booterstown, Co Dublin, and children living in the Killucan area of Westmeath.

Published in the 'Cambridge Journal of Hygiene' in 1971, the trial attempted to find out if German measles vaccine, administered intranasally, could spread to susceptible contacts.

Doctors

Both trials were carried out by Professor Irene Hillery and Professor Patrick Meenan, from the department of Medical Microbiology in University College Dublin, and other doctors.

The final trial involved 53 children from institutional homes. The homes were: St Patrick's Home, Madonna House, Cottage Home, Bird's Nest and Boheennaburna. A further 65 children living at home in Dublin also took part.

The purpose of the trial was to compare commercially available batches of the three-in-one vaccine, Trivax and Trivax AD, with that of a modified vaccine prepared for the trial.

Dr Kiely's report said the decision to conduct such clinical trials was acceptable, given the diseases that the vaccines sought to counter.

But, crucially, he insisted the lack of documentation available meant it had not been possible to confirm if consent had been given by the parents or guardians of the children involved or what arrangements were arrived at with managers of the homes.

He added that this lack of information also meant he could not confirm if the Therapeutic Substances Act 1932 had been complied with in relation to the licensing of the trials.

The damning document was laid before the Houses of the Oireachtas on November 7, 2000.

On November 9, the then Health Minister Micheal Martin told the Dail an important part of the probe was to establish if the State had fulfilled its obligations to children in its care.

But he admitted that the report was incomplete.

"It raises as many questions as it answers. Some of those questions go to the heart of our attitudes to children and their rights," he said at the time

"The report is incomplete because in some areas, the most rigorous interrogation of the system failed to produce documentary records of the trials."

Mr Martin said the Government had no evidence that any child had contracted a serious illness as a result of the trials.

But he branded the lack of documentation "puzzling" and insisted that the report had to be the "beginning and not the end" of the matter.

The minister referred the report of the investigation to the Commission to Inquire into Child Abuse -- known then as the Laffoy Commission.

A government order was subsequently made on June 19, 2001 to provide the commission with the powers to create a separate module to formally investigate the issues involved.

The 'Vaccines Module' initially convened a public sitting on January 23, 2002, to outline its terms of reference. It then began investigating the trials.

It obtained documents from GlaxoSmithKline, the successor of Wellcome, which allowed it to definitively identify the homes and people involved in the trials.

Investigators received so much information relating to trial one that they were able to identify the children given the 'four-in-one' vaccine.

It also conducted private interviews with witnesses to get a more accurate picture.

But just before the start of public hearings into the first trials, which were due to begin on June 17, 2003, the work of the commission was dealt a severe blow when the Supreme Court ruled that Prof Meenan did not have to give evidence.

Prof Meenan had appealed a High Court order requiring him to comply with the commission's direction to give evidence about his involvement in the trial.

The inquiry received a further setback when the Government's order directing the Laffoy Commission probe was held to be invalid by the High Court in November 2003.

Mr Justice Aindrias O Caoimh gave his decision in a challenge brought by Prof Hillery. However, he ruled that other machinery could exist for an appropriate inquiry.

Redress

On November 25, 2003, an undertaking was given to the High Court by the commission that it would not conduct any hearings in relation to matters within the ambit of the order.

It had been hoped that the Government would appeal this decision. But on November 2006, Health Minister Mary Harney ordered the vaccine module to be closed down.

Now, some of the victims have been left with no alternative but to seek redress in a US court after Ms Harney again firmly ruled out any further inquiries into existing or new allegations.

The victims' basic requests appear to be far from unreasonable; an apology for what was done to them; full medical screening to see if they have suffered any damaging long-term effects from the trials; and psychiatric counselling to help them get over their ordeal.
But even this, it appears, is beyond the capacity or willingness of the State to deliver.

- Patricia McDonagh

Irish Independent

Friday 20 August 2010

GSK criminals - Irish nuns may face lawsuit over human vaccine trials

Irish nuns may face lawsuit over human vaccine trials August 20, 2010


http://www.catholicculture.org/news/headlines/index.cfm?storyid=7279



An Irish religious order that operated maternity homes faces the prospect of a lawsuit over human vaccine trials that took place on babies there in 1960 and 1961.



Mari Steed, born at one of the homes and subsequently adopted by an American couple, discovered information about the vaccine trials as she searched for information about her birth mother. Steed's birth mother says that the experimental vaccine was administered to her daughter without her consent.



Steed and three others involved in the experiment are contemplating a lawsuit against the Sisters of the Sacred Heart and are preparing a class action lawsuit against the drug company GlaxoSmithKline.


Source(s): these links will take you to other sites, in a new window.

'I was used as a guinea pig in child vaccine scandal' (Belfast Telegraph)

GSK & Catholic church in secret baby vaccine trials Ireland - 'I was used as a guinea pig in child vaccine scandal'

'I was used as a guinea pig in child vaccine scandal'


http://www.belfasttelegraph.co.uk/news/local-national/republic-of-ireland/i-was-used-as-a-guinea-pig-in-child-vaccine-scandal-14918543.html

A woman subjected to a controversial vaccine trial as a baby without her mother's consent broke her silence last night to reveal her traumatic decades-long fight for justice.


Mari Steed (50) was effectively used as a guinea pig during the 'four-in-one' vaccine trials carried out on her between December 1960 and October 1961 when she was between nine and 18 months old.

She was given up for adoption to a couple in the US shortly afterwards and is now preparing a class action in the US courts against the multinational drugs giant responsible for the medical tests, an Irish Independent investigation reveals.

Ms Steed and three others who were also subjected to the trials are looking to separately sue the Catholic religious order that they claim facilitated the experiments in the early 1960s.

She was administered the vaccine on at least four occasions at the Sacred Heart Convent, Bessborough, in Cork, also known as the Bessborough Mother and Baby Home.

Ms Steed became aware she had been subjected to the vaccine trials after she retrieved her medical documents while trying to track down her mother, Josephine, in the late 1990s.

Josephine, who is now in a nursing home in the UK, last night said the tests were carried out on her baby daughter without her consent or knowledge of her medical history.

"They didn't ask me for my permission to give her that shot," she said.

Ms Steed, who now lives in Philadelphia, and a number of other victims in the US are taking the landmark case because repeated attempts to seek justice in the Republic of Ireland have failed.

She and the three others are planning to file a class action against the GlaxoSmithKline drug company in the US courts. GlaxoSmithKline was called 'The Wellcome Foundation' when the trials were conducted.

They are also hoping to separately take a case against the Sacred Heart Order -- either individually or as a group -- in the Irish courts.

Victims have queried if the religious order received any financial payment in return for the children being used in the trials. However, it has never been established if any payment was received.

"The trials involved incredibly poor judgment on the part of all involved. We were basically used as human guinea pigs," Ms Steed told the Irish Independent.

"There are at least four of us who are aware we were part of the trials, but there are probably more out there who don't know what happened to them."


At least 211 children were given the test vaccines during three separate drug trials, says a report commissioned by then-Health Minister Brian Cowen and drawn up by the Republic's Department of Health in 2000.

Ms Steed was involved in the first trial, which took place between December 1960 and November 1961 on 58 children in five children's homes. These included St Patrick's Mother and Baby Home, Dublin; the Bessborough Mother and Baby home in Cork; and St Peter's Mother and Baby Home, Castlepollard, Co Westmeath. Children from St Clare's Baby Home in Stamullen, Co Meath, and the Good Shepherd Mother and Baby Home in Dunboyne, Co Meath, also participated.

The trial examined what would happen if four vaccines for diphtheria (a life-threatening disorder caused by a highly contagious bacterial infection), pertussis (whooping cough), tetanus and polio were combined in one overall jab, known as the four-in-one shot.

However, the four-in-one jab never went into production after it failed to improve the previous standard vaccine.


Ms Steed's mother, Josephine, who was forced to give her daughter up for adoption to a US couple just months after the trials took place, insisted she never gave her consent for Mari to be used in the trial.

She added: "What happened to mothers, like myself, and the babies at that home was cruel. I am still angry and would like an apology for what happened."


However, the report concluded that it had not been possible to find documentation to confirm whether or not trials were licensed or received consent.


After its publication, the report was referred to the investigation of the Commission to Inquire into Child Abuse, then known as the Laffoy Commission. But court challenges from doctors involved in the trials prompted Health Minister Mary Harney to shut down the module without conclusion.

Ms Steed and other victims called on Ms Harney to publicly apologise on behalf of the State for what happened.

However, Ms Harney last night insisted there would be no further inquiries into the allegations already made. The minister also declined to say if she would apologise to the victims, or if the Government would provide life-screening or counselling.

Susan Lohan of the Adoption Rights Alliance said Ms Steed and other victims had been treated like "second-class" citizens.


A spokesman for the Sacred Heart Order said they would not make any comment until the case was taken. He said he was not aware of any other live actions against the order and insisted the issue surrounding the trials had been dealt with. A GlaxoSmithKline spokeswoman also refused to comment.

Irish Independent

Read more: http://www.belfasttelegraph.co.uk/news/local-national/republic-of-ireland/i-was-used-as-a-guinea-pig-in-child-vaccine-scandal-14918543.html#ixzz0x8Ig4UGB

Wednesday 11 August 2010

Seroxat Janice & John Simmons story

Janice & John's story - before Seroxat he took Prozac - now he takes Lustral




"Their GP said you will wait a year for that, and he put them both on Prozac. His wife went back within a week saying 'I feel like a zombie' but the doctor said it was just early days and she should keep on taking the tablets

http://www.huntspost.co.uk/home/anti_depressant_feature_woman_killed_herself_weeks_after_taking_drug_1_406712


Janice and John's story

JANICE'S husband John, a lorry driver, and his first wife (who he does not wish to name) were having problems with their marriage in 1991 and went to the doctor to seek counselling.


Janice said: "Their GP said you will wait a year for that, and he put them both on Prozac. His wife went back within a week saying 'I feel like a zombie' but the doctor said it was just early days and she should keep on taking the tablets. She tried to kill herself twice in three weeks and she succeeded the third time."

The couple's two children were then aged 10 and 12.

After his wife's suicide, John was prescribed Seroxat. He and Janice met six years later when she worked as a secretary for the company he drove for.

"He told me he was taking drugs. I said why. He said: 'If I stop taking them, I feel ill but I've been told by my doctor, they are not addictive.'

"I said if you feel ill when you stop taking them, they must be addictive and I started looking into it - now I would not trust a doctor to prescribe me anything."

She added: "It has now been recommended by the regulatory bodies, MHRA and NICE (The National Institute for Clinical Evidence) that anti-depressants should not be prescribed for natural grief or as a first-line treatment for mild depression.

"People are not offered counselling or therapy because it's easier to prescribe drugs and doctors are under pressure to use them.

"The average GP has three months training in psychiatry and mental health, unless they specialise, so doctors are listening to the drug companies instead of looking into things themselves."

She claimed: "Doctors don't take into consideration that when people say that a drug makes them feel bad, people know their own body. What suits one person will not suit another.

"Anti-depressants have a similar chemical structure to LSD and Ecstasy. They work on the neuro transmitters of the brain. We don't understand enough about the drugs or about the brain to be prescribing them at this level.

Tuesday 10 August 2010

Is Australia's "Number One Man" Misleading The Public ?

Is Australia's "Number One Man" Misleading The Public





Read more: McGorry 'misleading the public'


http://www.theage.com.au/national/mcgorry-misleading-the-public-20100808-11qes.html


check out also -  Seroxat User Group has no formal structure said Lord Hunt of Kings Heath




click for seroxatusergroup minutes http://www.seroxatusergroup.org.uk/SUG%20LH%20Meeting.pdf


-there must be some sort of formal structure to theSeroxat User Group

Sunday 8 August 2010

Seroxat Venlafaxine SSRI v SNRI Issue – Dr David Healy, CSM Expert Working Group Report and Tatsumi et al Study

Seroxat Venlafaxine SSRI v SNRI Issue – Dr David Healy, CSM Expert Working Group Report and Tatsumi et al Study

The Defining Issue of Seroxat Group Litigation Order No: 68, lodged at the High Courts by Lead Solicitors Hugh James, as follows -



“Does Seroxat have a capacity to cause asverse effects consequent upon or following discontinuance (withdrawl) such as prevent or make more difficult the ability of users to discontinue, withdraw from or remain free from taking Seroxat to a greater extent than all other Selective Serotonin Re-uptake Inhibitors (SSRIs)”

........... NB - spelling errors as per original document.

HM Courts Service: Seroxat Group Litigation Order no: 68.

specifying that the adverse effects of Seroxat are or have to be proven to be

“greater extent than all other Selective Serotonin Re-uptake Inhibitors (SSRIs)”

it appears the deciding factor of the Seroxat litigation – given venlafaxines’ shortest 5 hour half life– is dependant on each drugs classification.



In the “Halting SSRIs” document Dr David Healy opines (excerpt below) that venlafaxine is an SSRI up to doses of 150 mg.



He also states that although these drugs are called "Selective Serotonin Reuptake Inhibitor" (SSRIs) they are not “selective to the Serotonin system”, neither are they “pharmacologically “clean”” – meaning all drugs in the class to varying degrees also affect serotonin, noradrenalin and dopamine.





Click here to enlarge

The work by the Committee on Safety of Medicines (CSM), Expert Working Group (EWG) on SSRI Antidepressants, who’s report was published December 2004 confirms this aspect

“……When compared with tricyclic antidepressants, they are certainly more selective but still affect neurotransmitters other than serotonin in the central nervous system 8. This can be illustrated with reference to their binding affinities to the different monoamine transporters (table 5.1) 9. Furthermore, their effect is not limited to uptake inhibition. They have primary effects on many different receptors (see table 5.2), and also cause secondary changes in receptor numbers and receptor function at the synapse 8 10 11. The same principles also apply to the related antidepressants venlafaxine (which is mixed serotonin and noradrenaline reuptake inhibitor) and mirtazapine (which acts as an antagonist at the α2, 5HT2, 5HT3 and H1 receptors).”

The CSM EWG report Table 5.2 (below) shows the “Affinity” of each drug included in their investigation with reference to the “selective” nature and potency.







Click here to enlarge

………NB – The CSM Report was carried out prior to the SNRI duloxetine (Eli Lilly, Yentreve, Cymbalta – part developed by Boehringer Ingelheim) being licensed.



The findings show



citalopram (Lundbeck, Cipramil, Celexa) -- was - “highly selective”

sertraline (Pfizer, Lustral Zoloft) -- was the - “Second most potent”

paroxetine (GSK, Seroxat Paxil) -- was the - “Most potent, Lowest selectivity”

venlafaxine (Wyeth, Efexor Effexor) -- is listed as a - “re-uptake blocker” of NA = Noradrenaline and 5HT = 5-hydroxytryptamine = Serotonin



The CSM EWG report Table 5.1 (below) adapted from Tatsumi et al “Pharmacological profile of neuroleptics at human monoamine transporters” study paper originally published in the European Journal of Pharmacology 1999;368(2-3):277-83 shows the “Affinity” of each drug included in their investigation with reference to the potency of effects on three monoamine transporters, 5HT = serotonin, NA = noradrenaline and DA = dopamine.



Click here to enlarge

………NB – The CSM Report was carried out prior to the SNRI duloxetine (Eli Lilly, Yentreve, Cymbalta – part developed by Boehringer Ingelheim) being licensed.



The findings are valued using Kd or dissociated constant – as explained on the table the lower the Kd the higher the affinity to the transporter. Ignoring the tricyclic antidepressant comparator Amitriptyline and Norfluoxetine the drug Seproxetine which was investigated by Eli Lilly as an antidepressant, development was never completed and the drug as yet not marketed.



The findings -- Affinity Kd and (potency rating) -- show



citalopram - 1.2 Serotonin (Fourth) – 4070 Noradrenaline (Fifth) – 28100 Dopamine (Sixth)

sertaline - 0.3 serotonin (Second) – 420 noradrenaline (Third) - 25 Dopamine (First)

paroxetine - 0.1 serotonin (First) – 40 noradrenaline (First) - 490 Dopamine (Second)

venlafaxine - 152 serotonin (Sixth) – 9400 noradrenaline (Seventh) – 11700 Dopamine (Fifth)



In terms of classification and license applications it appears that Wyeth (now part of Pfizer) and Eli Lilly with their drugs venlafaxine, (Efexor Effexor) and duloxetine, (Yentreve, Cymbalta) are the only manufacturers to have been open in declaring the drugs additional action on noradrenaline (NA), in the case of Wyeth’s venlafaxine noradrenaline (NA) and dopamine (DA).



Venlafaxine is the only drug included in the CSM EWG investigation classified as an SNRI - however, according to the Tatsumi et al study accepted by the CSM EWG of the drugs classified as SSRIs – five have a higher Affinity and Potency to serotonin (5HT) – but six have a higher Affinity and Potency to noradrenalin (NA) - and four a higher Affinity and Potency to dopamine (DA).



Both SSRIs, Sertraline (Lustral, Zoloft) and paroxetine (Seroxat, Paxil), have considerably higher Affinity and Potency to all three transporters than the SNRI venlafaxine (Efexor, Effexor).



The SSRI Sertraline (Lustral, Zoloft) has at, Kd 0.3 the second highest Affinity and Potency to serotonin (5HT) and at Kd of 25 the highest Affinity and Potency to dopamine (DA), higher than all other drugs in the class.



The SSRI paroxetine (Seroxat, Paxil), at Kd 0.1 has the highest Affinity and Potency to Serotonin (5HT) and is the highest in Affinity and Potency, at Kd 40, to noradrenaline (NA) higher than all other drugs in the class.



The word “selective” seems to be an ambiguous descriptor of little or no value - all drugs in the SSRI, SNRI class, because they are not “pharmacologically “clean””, appear to have clear and unmistakable claim to being Serotonin, Noradrenaline and Dopamine Re-uptake Inhibitors.



With regard the SSRI v SNRI Issue – it appears the question is not whether venlafaxine can be considered an SSRI – but possibly whether paroxetine is actually an SNRI?

Thursday 5 August 2010

Seroxat the Discontinuation (Withdrawal) Issue - "Halting SSRIs" document by Dr David Healy

Seroxat the Discontinuation (Withdrawal) Issue - "Halting SSRIs" document by Dr David Healy






http://the-uk-seroxat-litigation-chronicles.blogspot.com/2010/07/seroxat-discontinuation-withdrawal_31.html







The Defining Issue of Seroxat Group Litigation Order No: 68, lodged at the High Courts by Lead Solicitors Hugh James, as follows -



"Does Seroxat have a capacity to cause asverse effects consequent upon or following discontinuance (withdrawl) such as prevent or make more difficult the ability of users to discontinue, withdraw from or remain free from taking Seroxat to a greater extent than all other Selective Serotonin Re-uptake Inhibitors (SSRIs)"



……….. NB - spelling errors as per original document.

HM Courts Service: Seroxat Group Litigation Order no: 68.



appears to be solely based on Seroxats' discontinuation problem being worse "than all other" SSRIs raises several questions with regard the propagation, collection, presentation and analysis of adverse drug reaction (ADR) reports; and the Medicines and Healthcare products Regulatory Agency (MHRA) the executive agency of the UK Governments Department of Health responsible for interpretation of the Yellow Card Scheme generated statistical drug analysis data and their ethics in accepting media (BBC Panorama) generated Yellow Card documentation - some collected through the Seroxat User Group.org website and support group, set up by Solicitor Hugh James for litigants.



It also raises the question of what the experts consider the cause of the discontinuation problem to be in relation to the pharmacokinetics of each drug in the class and which drugs are included in the SSRI class.



The "Halting SSRIs" document was prepared by Dr David Healy at the request of the MHRA, following their personal meeting in September 2008 with Seroxat campaigner Bob Fiddaman (SEROXAT SUFFERERS blog) who brought up the matter of an SSRI Withdrawal Protocol and suggested they liaise with the UK's Leading Authority on the SSRI, SNRI drug class to facilitate its production. The document was presented to the MHRA in June 2009.



The David Healy document "Halting SSRIs" states -



"There are 2 theories about what leads to dependence and withdrawal that dictate slightly differing management plans.

One theory is that the relatively short half life of paroxetine and venlafaxine make these two drugs more problematic. This leads to a withdrawal strategy that advocates switching from paroxetine or other drugs to fluoxetine.

The second is that paroxetine and venlafaxine are relatively more potent serotonin reuptake inhibitors and this theory leads to a switch to less potent serotonin reuptake inhibitors such as citalopram."

The theories highlight two problems - the drugs shortness of half-life and the drugs potency as a serotonin re-uptake inhibitor.



A drugs half-life is the average period of time the drug takes to reduce to or by half its original concentration once ingested - i.e. from 50mg to 25 mg, then from 25mg to 12.5 mg etc.



If the discontinuation problems are due to the short half-life of the drug - the December 2004 Committee on Safety of Medicines (CSM), Expert Working Group (EWG) on SSRI Antidepressants Report table 5.2 (below), shows that venlafaxine (Wyeth, Efexor UK, Effexor USA) has the shortest half-life at 5 hours, followed by paroxetine (GSK, Seroxat UK, Paxil USA) at 20 hours and sertraline (Pfizer, Lustral UK, Zoloft USA) at 26 hours.









Click here to enlarge

………NB – The CSM Report was carried out prior to the SNRI duloxetine (Eli Lilly, Yentreve, Cymbalta) being licensed.



The CSM, EWG report table 5.2 also indicates the drugs potency as serotonin re-uptake inhibitor and their affinity to monoamine transporters (MAT) – the selectivity of which has a bearing on the of the drugs classification.



Venlafaxine is classified by some as an SNRI, although in 1998 venlafaxine was listed in the Prescription Cost Analysis (PCA) statistics and British National Formulary, BNF: 4 . 3 . 3 . 0 SSRI section, in 1999 it was moved to PCA, BNF : 4 . 3 . 4 . 0 "Other Antidepressant Drugs" section where it remains. It's unclear whether this was at Wyeth, the manufacturers, request or a licensing classification decision.



In the "HALTING SSRIs" document Dr David Healy explains the following –

""SSRI stands for selective Serotonin reuptake inhibitor. This does not mean these drugs are selective to the serotonin system or that they are in some sense pharmacologically "clean". It means they have little effects on the norepinephrine/noradrenaline system."In the same document he also explains the following –



"Venlafaxine in doses up to 150 mg is an SSRI. Over 150 mg it also inhibits noradrenaline reuptake. Duloxetine is a potent serotonin reuptake inhibitor but not selective to the serotonin system."

Venlafaxine is the only drug in the SSRI, SNRI class with a recognised additional mode of action that is dose specific -- > 150 mg Selective Serotonin RI – 150 mg > Serotonin Noradrenaline RI - 300 mg > Serotonin Noradrenaline Dopamine RI.



It would appear that if the Discontinuation Issue were solely dependant on the individual drugs half-life, venlafaxine with a 5 hour half-life would be considered the worst drug. However, the Seroxat Group Litigation Order No: 68 Defining Issue wording specifically states -



"than all other Selective Serotonin Re-uptake Inhibitors (SSRIs)"

all drug in the class are classified Re-uptake Inhibitors (RI) - can the SNRI venlafaxine with it's recognised mode of Selective Serotonin RI action in doses up 150 mg be considered an SSRI? Are other SSRIs in the drug class, including Seroxat, which also have affinities to Noradrenaline and Dopamine correctly classified?